BIOMATBIOMATERIALS AND TISSUE ENGINEERING RESEARCH LABORATORY


Aylin Kömez

                                                      AylinKomez

                                                                                                                                           

Title: 

Researcher at Middle East Technical University Center of Excellence

in Biomaterials and Tissue Engineering (METU BIOMATEN)

Education: 

Ph.D. Department of Biotechnology, METU (2015-2019)

M.Sc. Department of Biotechnology, METU (2012-2015)

B.Sc. Department of Biology, METU (2008-2012)

Contact: 

Telephone: +90 312 210 5193

e-mail: komez.aylin@metu.edu.tr

            aylinkomez@gmail.com

Address:

METU BIOMATEN, Center of Excellence in Biomaterials and Tissue Engineering,

Üniversiteler Mah. Dumlupınar Blv. No:1, 06800 Çankaya, Ankara / TURKEY

 

Research Activities


Development of A Bone Tumor Model Under In Vitro Conditions 


The aim of this study was to develop a three dimensional (3D) bone tumor model (BTM) by using tissue engineering approach and to investigate its ability to serve as a model to test the efficacy of anticancer drugs. Lyophilized 3D scaffolds were used to create osteosarcoma under in vitro conditions. Responsiveness of the developed model to cytotoxic drugs were studied as an indicator of mimicking of the bone tumor. The 3D tumor model would help establish an environment similar to natural physiological media for testing and development of drugs in a high throughput manner without having to use animal testing. In addition, it could also provide personalized medicine by selecting the most effective drugs and drug combinations for individual patients since patient’s own cells could be used in the 3D model.


The construction of Bruch’s membrane by using tissue engineering approach to repair retinal degenerations


The aim of this study is to develop a Bruch’s membrane substitute, a membrane that has important roles in the regeneration of retina and regulation of functions of retinal pigment epithelium cells. The multilayer construct will consist of electrospun layers of biopolymers treated with natural Bruch’s membrane components. Vascular layer will be included to mimic the choroid of the eye to provide nutrients and oxygen to the retinal pigment epithelium cells that will be seeded on the construct. 


RetGraphAbs



SCI Publications


Komez A., Buyuksungur A., Antmen E., Hasirci N., Hasirci V. (2019). 3D Bone Tumor Model Designed as Two Compartment Can Show Interactions and Migrations of Cells and Efficacy of Cancer Drugs. (Submitted)

Komez A., Buyuksungur S., Hasirci V., Hasirci N. (2018). Effect of chemical structure on properties of polyurethanes: Temperature responsiveness and biocompatibility. Journal of Bioactive and Compatible Polymers,  33(5):479-497. 

Komez A., Baran E. T., Erdem U., Hasirci N., Hasirci V. (2016). Construction of a Patterned Hydrogel - Fibrous Mat Bilayer Structure to Mimic Choroid and Bruch’s Membrane Layers of Retina. Journal of Biomedical Materials Research Part A, 104(9):2166-2177.


Book Chapters


Hasirci N., Kilic C., Komez A., Bahcecioglu G., Hasirci V. (2016). Hydrogels in Regenerative Medicine, in: U. Demirci, A. Khademhosseini. Gels Handbook Fundamentals, Properties and Applications, World Scientific Publishing, Singapore.


Proceedings and Symposia


Komez A., Buyuksungur A., Antmen E., Hasirci N., Hasirci V. İn Vitro Koşullarda 3 Boyutlu Kemik Tümör Modeli Geliştirilmesi. 23. Biyomedikal Bilim ve Teknoloji Sempozyumu (BIOMED2018-TR), 15-16 December, 2018, İstanbul, Turkey (Poster Presentation).

Komez A., Buyuksungur A., Antmen E., Hasirci N., Hasirci V. Development of an in vitro 3D Bone Tumor Model. 2nd International Biomedical Engineering Congress 2018 (IBMEC-2018), 24-27 May 2018, North Cyprus (Oral Presentation).

Komez A., Baran E.T., Hasirci N., Hasirci V. Construction of Retina Substitute by Using Tissue Engineering Approach. 1st East West Asia Biomaterials Symposium EWAB 2015, 21 October 2015, Antalya, Turkey (Oral Presentation).

Komez A., Baran E.T., Hasirci N., Hasirci V. Construction of Retina Substitute by Using Tissue Engineering Approach. International Symposium on Biomedical Science & Technology (BIOMED), October 2015, Antalya, Turkey (Poster Presentation).

Komez A., Buyuksungur S., Hasirci V., Hasirci N. Synthesis of Polyurethane for Coating of Neurostimulator. BIOMED 2015, October 2015, Antalya, Turkey (Poster Presentation).

Komez A., Baran E.T., Hasirci N., Hasirci V. Vascular network generation in hyaluronic acid by micromolding and photoimmobilization of fibronectin, 26th Annual Conference of the European Society for Biomaterials (ESB), 31 August – 3 September 2014, Liverpool, UK (Oral Presentation)


Projects


2016-2018 TUBİTAK_Poland Bilateral Cooperation Project, Development of a Bone Tumor Model with 3D Printed and Lyophilized Scaffolds (Project No:215M621), PhD Thesis Project

2012-2015 METU‐GATA (Gülhane Military Medical Academy) Joint Project, Construction of Artificial Retina Substitute with Tissue Engineering Approach for Treatment of Retinal Injuries (Project No: 08–11‐2013–039)

2012-2014 METU Scientific Research Projects (METU, BAP), Construction of Retina Substitute by Using Tissue Engineering Approach

2011-2012 EU-FP7 Skin Treat Project, Graduation Project