BIO 554 - Macromolecules in Biotechnology and Biomedicine


Credits:  (3-0) 3
Prerequisite:  Consent of the Instructor




Classification, synthesis and transformation of biopolymers (polynucleotides, polypeptides and polysaccharides). Merrifield solid state synthesis. Classification, synthesis and transformation of synthetic macromolecules. Chemical and biological transformation. Solution behavior, helix-coil transition. Structure, morphology and properties of biological polymers in the solid state. Single crystal formation. Applications in Biomedicine and Biotechnology.(S/WE)*


Course Outline:


  • Introduction
  • Classification of Macromolecular Compounds
  • MW and Polymolecularity
  • Synthesis of Synthetic Polymers
  • Synthesis of Macromolecules With Heteroatoms In The Chain Via Polycondensation
  • Solid State Synthesis of Proteins
  • Strategies For Chemical Synthesis of DNA
  • Chemical Transformation
  • The Macromolecular Solution
  • The Peptide Bond Structure and Morphology of Biopolymers
  • a-Helix and Single crystal
  • Free Energies, Bonding Types and Conformation
  • Packing density
  • Macromolecular Symmetry
  • Specific Biopolymers
  • Recent Papers


Reference Books:


  • Biotechnology and Bioactive Polymers, C.G.Gebelein, C.H.Carraher, Jr., Plenum Press, 1994
  • Immobilized Macromolecules, U.B.Sleyr, P.Messner, D.Pum, M.Sara, Springer- Verlag,1993
  • Biosensors, A.E.G.Cass, IRL Press,1990
  • Biopolymers, A.G.Walton, J.Blackwell, S.H.Carr, Academic Press, 1973
  • Biophysical Chemistry, C.R.Cantor, P.R.Schimmel, W.H.Freeman and Co.,1980
  • Polysaccharides, E.D.T.Atkins, Macmillan,1985