BIOMATBIOMATERIALS AND TISSUE ENGINEERING RESEARCH LABORATORY


Dilara Göksu Tamay

                                                                          DilaraTamay

 

 

Title: 

Research Specialist at Center of Excellence in Biomaterials and Tissue Engineering, METU

Ph.D. Student at BIOMAT, METU

Education: 

Ph.D. Biotechnology, Middle East Technical University, Ankara, Turkey (2021 – Present)

M.Sc. Biotechnology, Middle East Technical University, Ankara, Turkey (2016 – 2019)

B.Sc. Bioengineering, Marmara University, Istanbul, Turkey (2011 – 2016)


Contact:

e-mail: dilara.tamay@metu.edu.tr

            dilaratamay@gmail.com

phone: +90 312 210 5191

Address:

BIOMATEN, Biyoteknoloji Arastirma Laboratuvarı, ODTU, Universiteler Mh. Dumlupinar Blv. No:1, 06800, Cankaya, Ankara, Turkey.



Research Areas of Interest:


Biomaterials, Nerve Tissue Engineering, Additive Manufacturing, Micro/Nanofabrication, Cell-Surface Interactions


Research Field:


Investigating the contribution of micropatterns and cell-cell interactions on nerve regeneration.


Engineering nerve guides with specific microarchitecture and involvement of certain cell types affect neuron and Schwann cell behaviors such as attachment, axon direction and growth, and axonal growth cone migration, which are all advantageous in repairing a peripheral nerve defect rapidly and efficiently. My PhD studies involve combining micropatterned surfaces and chemotaxis agents for aligned growth of peripheral axons and investigating the contribution of different types of cells on the migration of growth cones across the nerve gap. 


Design and performance evaluation of nerve guides with physical and chemical axon elongation cues.


Nerve guides are tubular constructs designed to form a bridge between the transected nerve ends, provide physical support, and achieve axon guidance via topographical and/or chemical cues. The aim of my M.Sc. study was to develop and assess the in vitro performance of a customizable 3D printed tubular nerve guide with a hydrogel inner matrix containing topographical alignment cues, capable of releasing chemical axon elongation enhancers.


Publications:


  • Tamay, D. G., Gokyer, S., Schmidt, J., Vladescu, A., Yilgor Huri, P., Hasirci, V., and Hasirci, N. (In Press). Corrosion Resistance and Cytocompatibility of Magnesium Calcium Alloys Modified with Zinc or Gallium Doped Calcium Phosphate Coatings. ACS Appl. Mater. Interfaces.
  • Tamay, D. G. and Hasirci, N. (2021). Bioinks—materials used in printing cells in designed 3D forms. J. Biomater. Sci. Polym. Ed., 32(8), 1072-1106. doi: 10.1080/09205063.2021.1892470
  • Tamay, D.G., Dursun Usal, T., Alagoz, A.S., Yucel, D., Hasirci, N. and Hasirci, V. (2019). 3D and 4D Printing of Polymers for Tissue Engineering Applications. Front. Bioeng. Biotechnol. 7:164. doi: 10.3389/fbioe.2019.00164


Projects:


  • 2021-Cont. TUBITAK ARDEB 1001 (Project No: 120R071), Production of a Nerve Tissue Model on a Micropatterned Surface, Investigation of Axon Guidance and Nerve Damage Healing (Researcher).
  • 2019-2020 ERA.Net RUS Plus 2017 on Innovation - TUBITAK TEYDEB 1509 (Project No: 9180035), Biodegradable and Non-Biodegradable Orthopedic Implants with Bactericidal Coatings and Controllable Degradability (CoatDegraBac) (Researcher). 


Proceedings and Symposia:


  • Tamay, D. G., Gokyer, S., Schmidt, J., Vladescu, A., Yilgor Huri, P., Hasirci, V., and Hasirci, N. (2021). Çinko/Galyum Katkılı, Kalsiyum Fosfat Kaplamalı, Magnezyum-Kalsiyum İkili Alaşımların İn Vitro Aşınma Dayanımı ve Hücre Uyumluluğunun İncelenmesi. 25. Ulusal Biyomedikal Bilim ve Teknoloji Sempozyumu (BIOMED2021-TR), 18-19 December 2021, Ankara, Turkey (Online) (Oral Presentation).
  • Tamay, D. G., Ozen, C., and Hasirci, V. (2019). Design and In Vitro Testing of a Peripheral Nerve Guide. 24th Biomedical Science and Technology Symposium (BIOMED 2019), 17-20 October 2019, Izmir, Turkey (Poster Presentation).
  • Tamay, D. G., Hasırcı, V., and Özen, C. (2018). Periferal Sinir Yönlendiricisi Tasarımı ve In Vitro Koşullarda Denenmesi. 23. Ulusal Biyomedikal Bilim ve Teknoloji Sempozyumu (BIOMED2018-TR), 15-16 December 2018, Istanbul, Turkey (Poster Presentation).