BIOMATBIOMATERIALS AND TISSUE ENGINEERING RESEARCH LABORATORY


Ezgi Antmen

 

 

Title: 

Research Specialist at Middle East Technical University Center of Excellence

in Biomaterials and Tissue Engineering (METU BIOMATEN).

Content Manager for Biomaterials and Tissue Engineering Society (BTES)’s web page BDMD

Education: 

Ph.D. Department of Biotechnology, METU (2013-2017)

M.Sc. Department of Biology, METU (2011-2013)

B.Sc. Department of Molecular Biology and Genetics, METU (2007-2011)

Contact: 

Telephone: +90 312 210 53 41

e-mail: ezgiantmenn@gmail.com

            eantmen@metu.edu.tr

 

 

Research Field

 

Cell-Material Interactions

It was observed that cancerous and healthy cells show behavioral differences on surfaces with micro and nano features in their attachment, migration, proliferation and deformation. It was observed that nuclei of the cancer cells were deformed when they were seeded on certain micropatterned surfaces especially when the distance between the features was enough for a cell to slip in between two features. These differences are expected to be a key to understanding cancer cell behavior and detection. Several detection methods including lab-on-a-chip devices are being considered to make the process easy, reproducible and accurate, and to allow reduction in reagent consumption and process time.


SCI Publications


Antmen E., Ermis M., Demirci U., & Hasirci V. (2019). Engineered Natural and Synthetic Polymer Surfaces Induce Nuclear Deformation in Osteosarcoma Cells. Journal of Biomedical

Materials Research Part B: Applied Biomaterials, 107(2), 366-376.

Ermis M*., Antmen E.*, & Hasirci, V. (2018). Micro and Nanofabrication Methods to Control Cell-Substrate Interactions and Cell Behavior: A Review from The Tissue Engineering Perspective. Bioactive Materials, 3(3), 355-369. (*Co-authors)

Antmen E., Demirci U., Hasirci V. Enhancement of Nuclear Deformation of Breast Cancer Cells to Distinguish Their Malignancy. (Under Revision: Materials Science and Engineering C)

Komez A., Buyuksungur A., Antmen E., Hasirci N., & Hasirci V. Development of a Bone Tumor Model under In Vitro Conditions. (Under Revision: Biomaterials)

Antmen E., Demirci U., Hasirci V. Role of Actin Filaments in the Nuclear Deformability of Breast Tumor Cells. (In Preparation)

Antmen E., Ermis M., Hasirci V. Effect of Topography on Breast Cancer Cell Morphology, Proliferation, Metabolism and Cell Cycle. (In Preparation)


Book Chapters


Ermis M., Sayın E., Antmen E., Hasirci V. Extracellular Matrix, Cell Adhesion, Cell Substrate Interactions, Mechanobiology. (2019). Biological Soft Matter. John Wiley & Sons. (Submitted)

Ermis M., Baran E. T., Dursun T., Antmen E., Hasirci V. Contribution of Physical Forces on the Design of Biomimetic Tissue Substitutes. Brennan, A. B., & Kirschner, C. M. (Eds.). (2014).

Bio-inspired Materials for Biomedical Engineering. John Wiley & Sons, pp. 59-76, ISBN: 978-1-118-36936-4.


Proceedings and Symposia

Antmen E., Ermis M., Hasirci V. Potential of Micro-Nanopatterned Surfaces as Biomaterials and In Diagnostics. IV. In Vitro Diagnostic (IVD) Symposium, Feb 20-22, 2019, İzmir, Turkey. (Oral presentation).

Antmen E., Demirci U., Hasirci V. Effect of Mechanotransduction Proteins on the Nuclear Deformation of Breast Cancer Cells. BIOMED, Dec 15-16, 2018, İstanbul, Turkey. (Oral presentation).

Antmen E., Demirci U., Hasirci V. Nuclear Shape Analysis of Breast Cancer Cells for Distinguishing by Their Malignancy. IBMEC, May 24-27, 2018, North Cyprus. (Poster presentation).

Antmen E., Demirci U., Hasirci V. Engineered Surfaces to Screen Breast Cancer Cells. ESB, September 4-8, 2017, Athens, Greece. (Poster presentation).

Antmen E., Demirci U., Hasirci V. Micropatterned Surfaces to Screen Breast Tumor Cells. BIOMED, May 12-14, 2017, Ankara, Turkey. (Oral presentation).

Antmen E., Ermis M., Demirci U., Hasirci V. Effect of Micropatterned Surfaces on Cell Adhesion and Nuclear Deformation of Saos-2 Cells on PLGA and Collagen Films. FBPS, July 8-11, 2015, Riva del Garda, Italy. (Oral presentation).

Antmen E., Ermis M., Demirci U., Hasirci V. Effect of Micropatterned Surfaces on Cell Adhesion and Nuclear Deformation of Saos-2 Cells on Collagen and PLGA Films. BIOMED, October 22-24, 2015, Antalya, Turkey (Poster presentation).

Ermis M., Antmen E., Chen P., Gurkan U. A., Demirci U., Hasirci V. Effect of Micropatterned PLGA and Collagen Surfaces on Cell Adhesion and Nuclear Deformation. MRS Fall Meeting, December 1-6, 2013, Boston, MA, ABD. (Poster presentation).


Projects

2019 TÜBİTAK, Bilateral Cooperation Program with the Polish National Research and Development Center (NCBR), Cancer Cell Metastasis in Two Different Tissue Models (218S765) (Researcher) (Under Evaluation)

2019 EuroNanoMed III-JTC2019 (ERA-Net on Nanomedicine), Nanoparticle Loaded Injectable Hydrogels for Breast Cancer Treatment and Tissue Regeneration (119S155) (Researcher) (Under Evaluation)

2017–2018 TÜBİTAK, Bilateral Cooperation Program with the Polish National Research and Development Center (NCBR), Development of a Bone Tumor Model with 3D Printed and Lyophilized Scaffolds (215M621) (Postdoctoral Researcher)

2015-2017 METU BAP, Cell-Material Interactions and Cell Fate (BAP-08-11-KB.2016K-12520) (Coordinator)

2011-2012 METU BAP, The Effect of ELP and Collagen Scaffolds on Physical Properties, Cell Attachment and Differentiation of Cells (BAP-07.02.2012.101) (Researcher)