BIOMATBIOMATERIALS AND TISSUE ENGINEERING RESEARCH LABORATORY


Gözde Eke

 

 

Title: 

Research Assistant at Ahi Evran University

Postdoctoral Researcher at Center of Excellence in Biomaterials and Tissue Engineering (BIOMATEN)

Education: 

PhD. Biotechnology Programme, METU, 2018

M.Sc. Micro and Nanotechnology Programme, METU, 2011

B.Sc. Chemical Engineering, Ankara University, 2007.

Contact:
Telephone: +90 312 210 5189

e-mail: e168923@metu.edu.tr

 

 

MSc. Thesis: 


Biopolymer based nanoparticles as drug carriers for the treatment of skin diseases

In the frame of EU-FP7 Skin Treat Project:

Controlled drug delivery systems are becoming increasingly sophisticated with the contribution of nanotechnology. In the case of transdermal applications the greatest limitation is the highly impermeable outermost layer of the skin, the stratum corneum. One promising method of controlled transdermal drug delivery of the skin therapeutics is the use of nanoparticles as carriers. Encapsulation of the drug, as opposed to classical topical application of creams or emulsions, allows the drug to diffuse into hair follicles where drug release can occur in the deeper layers of the skin. 

The aim of this study was to develop micro and nano sized carriers as drug delivery systems to achieve treatment for skin conditions like psoriasis, aging or UV damage, caused by radiation or health problems. Two different types of bioactive agents, retinyl palmitate (RP) and Dead Sea Water (DSW), were used by encapsulating in poly(3-hydroxybutyrate-co-3-hydroxyvalerate) carriers.

  

Selected Publications:

  • Mangır, N., Eke, G., Hasirci, N., Chapple, C. R., Hasirci, V., MacNeil, S. (2019). An Estradiol releasing hydrogel to be used as a proangiogenic biomaterial for use as a tissue interposition graft in urogenital reconstruction. Journal of Neurourology and Urodynamics, 1-8. DOI: 10.1002/nau.23971
  • Şahin, A., Eke, G., Buyuksungur, A., Hasirci, N., & Hasirci, V. (2018). Nuclear targeting peptide-modified, DOX-loaded, PHBV nanoparticles enhance drug efficacy by targeting to Saos-2 cell nuclear membranes. Journal of Biomaterials Science, Polymer Edition, 29(5), 507-519. DOI: https://doi.org/10.1080/09205063.2018.1423812
  • Eke, G., Mangir, N., Hasirci, N., MacNeil, S., & Hasirci, V. (2017). Development of a UV crosslinked biodegradable hydrogel containing adipose derived stem cells to promote vascularization for skin wounds and tissue engineering. Biomaterials, 129, 188-198. DOI: 10.1016/j.biomaterials.2017.03.021
  • Eke, G., Goñi-de-Cerio, F., Suarez-Merino, B., Hasirci, N., & Hasirci, V. (2015). Biocompatibility of Dead Sea Water and retinyl palmitate carrying poly (3-hydroxybutyrate-co-3-hydroxyvalerate) micro/nanoparticles designed for transdermal skin therapy. Journal of Bioactive and Compatible Polymers, 30(5), 455-471. DOI: 10.1177/0883911515585183
  • Eke, G., Kuzmina, A. M., Goreva, A. V., Shishatskaya, E. I., Hasirci, N., & Hasirci, V. (2014). In vitro and transdermal penetration of PHBV micro/nanoparticles. Journal of Materials Science: Materials in Medicine, 25(6), 1471-1481. DOI: 10.1007/s10856-014-5169-5


Proceedings:

  • G. Eke, N. Mangir, N. Hasirci, S. Macneil, V. Hasirci. A UV crosslinked IPN hydrogel loaded with ADSC to promote vascularization for tissue engineered skin. Termis European Congress. European Cells and Materials. 2017. 34(1). 1473-1474.
  • Eke, G., Mangir, N., Hasirci, N., Chapple, C., Hasirci, V., & Macneil, S. (2017). Estradiol releasing hydrogel as a proangiogenic substitute for fat flaps used in urogenital reconstruction. European Urology Supplements, 16(3), e336-e337. DOI: https://doi.org/10.1016/S1569-9056(17)30259-2
  • V. Hasirci, A. Sahin, G. Eke. Delivery of drugs into Cells with PHBV Nanoparticles. 4th TERMIS World Congress, TISSUE ENGINEERING PART A. 08-11 September 2015, Boston, USA. 21(1). S349-S349


Presentations:

  • Eke G., Kuzmina A.M., Goreva A.V., Shishatskaya E.I., Hasirci N., Hasirci V. In vitro and In vivo transport of PHBV micro/nanoparticles. European symposium on biopolymers (ESBP 2013), 7-9 October 2013, Lisbon, Portugal (Oral presentation).
  • Eke G., Hasirci N., Hasirci V. In vitro and In vivo study of biopolymer based micro/nanoparticles with different sizes for transdermal applications. Summer School on biomaterials and regenerative medicine, 9-13 July 2012, Trento, Italy (Oral Presentation).
  • Eke G., Kucukturhan A., Kardesler S., Yilgor P., Hasirci N., Hasirci V. Nanoparticles as drug carriers for the treatment of skin diseases. 6th nanoscience and nanotechnology conference - NANOTR VI, 15-18 June 2010, İzmir, Turkey (Oral Presentation).
  • Eke G., Hasirci N., Hasirci V. Biyopolimerik nano-mikroparçacıkların ilaç salım sistemleri olarak deri hastalıkları tedavisinde kullanımı. 3. ulusal polimer bilim ve teknoloji kongresi, 12-14 Mayıs 2010, Kocaeli, Turkey (Poster).
  • Kardesler S., Eke G., Kucukturhan A., Yilgor P., Hasirci N., Hasirci V. Topical delivery systems for the treatment of skin diseases. International symposium of biotechnology, 27-30 September 2009, Ankara, Turkey (Poster).


Book Chapters:

  • Hasirci, V., Huri, P. Yilgor, Tanir, T. Endogan, Eke, G., and Hasirci, N. (2017) 1.22 Polymer Fundamentals: Polymer Synthesis. In: Ducheyne, P., Grainger, D.W., Healy, K.E., Hutmacher, D.W., and Kirkpatrick, C.J. (eds.), Comprehensive Biomaterials II,  1.  pp. 478–506. Oxford: Elsevier. DOI: http://dx.doi.org/10.1016/B978-0-12-803581-8.10208-5
  • Hasirci V., Yilgor P., Endogan T., Eke G., Hasirci N. Polymer fundamentals: Polymer synthesis, in: Ducheyne P., Healy K., Hutmacher D., Grainger D.W., Kirkpatrick. C.J. Comprehensive biomaterials 2011; 1: 349-371.
  • Demirbağ B., Kardesler S., Buyuksungur A., Kucukturhan A., Eke G., Hasirci N., Hasirci V. Nanotechnology in biomaterials: Nanoparticulates and drug delivery systems, in: Reisner D.E. Bionanotechnology global prospects II. CRC Press, New York 2011.