BİOMATBIOMATERIALS AND TISSUE ENGINEERING RESEARCH LABORATORY


Menekşe Ermiş

 

 

Title: 

Ph.D Student in Biomedical Engineering, METU

Research Specialist in METU Center of Excellence in Biomaterials and Tissue Engineering

Education: 

MD School of Medicine, Hacettepe University, 2009.

Contact: 
Telephone: +

90 312 210 53 41

e-mail:menekse.ermis@metu.edu.tr

Address:

BIOMATEN, METU Center of Excellence in Biomaterials and Tissue Engineering Biotechnology Research Unit Bldg. Ankara 06800, Turkey


Research Field:


Study of Cell-Substrate Interactions using Engineered Topographies:

Many different cell types that make up tissues and organs of an organism are adherent. Therefore cell adhesion is a very important process among many cell types. It is the binding process of a cell to extracellular matrix, a surface or another cell through some specific surface proteins. Developing surface patterning technologies at micro and nano-scale paved the road to study cell-surface interaction from a completely novel point of view. Creating topographies with geometrical micro and nanopatterns, like channels, pillars and pits with controlled dimensions become available through various methods. Cells cultured on these two dimensional structures show various shape changes from alignment to deformation. These kinds of topographical cues not only distort and deform cell but also effect nucleus within. Recent studies were able to demonstrate that particular cell types are more prone the nuclear deformation. Nuclear deformation observed under static stimulation of micropillars differs among different cell types. By designing and engineering micropatterned surfaces cell adhesion, morphology, metabolism, proliferation and differentiation can be controlled using physical cues.

 

Selected Publications:


Hasturk O., Ermis M., Chen P., Demirci U., Hasirci V. Interaction of Nondegradable, Stiff Hydrophobic Polymers with Human Osteoblast Like Cells. BIOMED, August 24-27, 2014, Köyceğiz, Muğka, Turkey (Oral presentation).

Ucar S., Ermis M., Hasirci V., Hasirci N. Mineralized Chitosan Scaffolds for Bone Tissue Engineering Applications. BIOMED, August 24-27, 2014, Köyceğiz, Muğka, Turkey (Poster presentation).

Ermis M., Baran E. T., Dursun T., Antmen E., Hasirci V. Contribution of physical forces on the design of biomimetic tissue substitutes. Brennan, A. B., & Kirschner, C. M. (Eds.). (2014). Bio-inspired Materials for Biomedical Engineering. John Wiley & Sons, pp. 59-76, ISBN: 978-1-118-36936-4.

Ermis M., Antmen E., Gurkan U. A., Demirci U., Hasirci V. Effect of Micropatterned PLGA and Collagen Surfaces on Cell Adhesion and Nuclear Deformation. MRS Fall Meeting, December 1-6, 2013, Boston, MA, ABD. (Poster presentation).

Ermis M., Bahcecioglu G., Kandemir B., Hasirci V. Kök hücreler, rejeneratif üroloji, ve doku mühendisliği, in Moleküler Üroloji, Eds. L. Turkeri, A. Ozer, F. Narter, Publisher Uronkoloji Dernegi, Istanbul (Turkey), pp. 721-748, 012, ISBN 978-975-01697-2-4.

Ermis M., Gurkan U. A., Demirci U., Hasirci V. Physical Functionalization of Polymeric Surfaces by Micro-Patterning of PLGA Films to Study Cell-Material Interactions. TERMIS-EU Chapter Meeting, 17-20 June 2013, Istanbul, Turkey. (Oral Presentation)