BIOMATBIOMATERIALS AND TISSUE ENGINEERING RESEARCH LABORATORY


Menekşe Ermiş

 

 

Title: 

M.D., Ph.D.

Research Specialist in METU Center of Excellence in Biomaterials and Tissue Engineering

Education: 

Ph.D. Biomedical Engineering, Middle East Technical University, 2016.

M.D. School of Medicine, Hacettepe University, 2009.

Contact: 
Telephone: +90 312 210 53 41

e-mail: ermism@metu.edu.tr, e.menek@gmail.com

Address:

BIOMATEN, METU Center of Excellence in Biomaterials and Tissue Engineering Biotechnology Research Unit Bldg. Ankara 06800, Turkey


Research Field:


Study of Cell-Substrate Interactions using Engineered Topographies:

Many different cell types that make up tissues and organs of an organism are adherent. Therefore cell adhesion is a very important process among many cell types. It is the binding process of a cell to extracellular matrix, a surface or another cell through some specific surface proteins. Developing surface patterning technologies at micro and nano-scale paved the road to study cell-surface interaction from a completely novel point of view. Creating topographies with geometrical micro and nanopatterns, like channels, pillars and pits with controlled dimensions become available through various methods. Cells cultured on these two dimensional structures show various shape changes from alignment to deformation. These kinds of topographical cues not only distort and deform cell but also effect nucleus within. Recent studies were able to demonstrate that particular cell types are more prone the nuclear deformation. Nuclear deformation observed under static stimulation of micropillars differs among different cell types. By designing and engineering micropatterned surfaces cell adhesion, morphology, metabolism, proliferation and differentiation can be controlled using physical cues.

 

SCI Publications:


Ermis, M.*, Antmen, E.*, & Hasirci, V. Micro and Nanofabrication methods to control cell-substrate interactions and cell behavior: A review from the tissue engineering perspective. Bioactive Materials, 3(3), 355-369, (2018), 10.1016/j.bioactmat.2018.05.005.

Hasturk, O.*, Ermis, M.*, Demirci, U., Hasirci, N., & Hasirci, V. Square prism micropillars improve osteogenicity of poly (methyl methacrylate) surfaces. Journal of Materials Science: Materials in Medicine, 29(5), 53, (2018), 10.1007/s10856-018-6059-z. (IF: 2.448)

Antmen, E., Ermis, M., Demirci, U., & Hasirci, V. Engineered natural and synthetic polymer surfaces induce nuclear deformation in osteosarcoma cells. Journal of Biomedical Materials Research Part B: Applied Biomaterials (2018), 10.1002/jbm.b.34128. (IF: 3.189)

Ermis, M., Akkaynak D., Chen P., Demirci U., and Hasirci V. A high throughput approach for analysis of cell nuclear deformability at single cell level. Scientific Reports 6 (2016), 10.1038/srep36917. (IF: 5.288)

Ucar S., Ermis M., Hasirci N. Modified chitosan scaffolds: Proliferative, cytotoxic, apoptotic, and necrotic effects on Saos-2 cells and antimicrobial effect on Escherichia coli. Journal of Bioactive and Compatible Polymers: Biomedical Applications, 31(3): 304–319, (2016), 10.1177/0883911515627471. (IF: 2.5) 


Book Chapters:


Antmen E., Sayin E., Ermis M., Hasirci V. Extracellular matrix, cell adhesion, cell substrate interactions, mechanobiology. Biological Soft Matter, Corrine Nardine (Ed.) (in press), Wiley and Sons.

Ermis M.*, Calamak S.*, Calibasi-Kocal G., Guven S., Durmus G.N., Rizvi I., Hasan T., Hasirci N., Hasirci V., Demirci U. Hydrogels as a New Platform to Recapitulate the Tumor Microenvironment. Ashutosh Tiwari (Eds.) (2018) Handbook of Nanomaterials for Cancer Theranostics: from the Chemical to the Biological Realm. Elsevier, pp. 463-488, ISBN: 9780128133408.

Ermis M., Baran E. T., Dursun T., Antmen E., Hasirci V. Contribution of physical forces on the design of biomimetic tissue substitutes. Brennan, A. B., & Kirschner, C. M. (Eds.). (2014). Bio-inspired Materials for Biomedical Engineering. John Wiley & Sons, pp. 59-76, ISBN: 978-1-118-36936-4.

Ermis M., Bahcecioglu G., Kandemir B., Hasirci V. Kök hücreler, rejeneratif üroloji, ve doku mühendisliği, in Moleküler Üroloji, Eds. L. Turkeri, A. Ozer, F. Narter, Publisher Uronkoloji Dernegi, Istanbul (Turkey), pp. 721-748, 012, ISBN 978-975-01697-2-4.

Proceedings and Symposia:


Ermis, M., Akkaynak, D., Chen, P., Demirci, U., & Hasırcı, V. Nucleus deformation on micropatterned substrates: A tool to quantify nuclear deformability of cancer cells. IBMEC’18,Second International Biomedical Engineering Conference, 24-27 May 2018, Northern Cyprus.

Ermis M. Bir Mikroçiple Kanseri Saptamak, ODTÜ Sanayi Günleri Günleri 2018 ,16 February 2018, Ankara, Türkiye (Oral presentation).

Ermis M. Bir Mikroçiple Kanseri Saptamak: Prenses ve Bezelye Tanesi Hikayesi, ODTÜ DAS ,5 February 2018, Ankara, Türkiye (Oral presentation).

Ergene E., Bilecen D. S., Ermis M., Huri, P. Y., Hasirci V. 3D Cellular Alignment Enhance ASC Myogenesis for Skeletal Muscle Tissue Engineering. 28th Annual Conference of the European Society For Biomaterials (ESB), 4-8 Eylül 2017, Atina, Yunanistan (Oral presentation).

Ermis M., Hasirci N., Hasirci V. Mesenchymal stem cell and HUVEC spheroids embedded in GelMA as a vascularization strategy for engineered soft tissues. BIOMED, 12-14 Mayıs 2017, Ankara, Türkiye (Sözlü sunum).

Ermis M. Biyobasım sonrası Doku Görüntülenmesi: Konfokal Mikroskopi, 02 November 2016, Kocaeli University, Kocaeli, Turkey (Oral presentation).

Akca, G., Celik, I., Ermis, M., Foto, E. Imaging the interactions between oral pathogens and probiotic lactic acid bacteria on the adhesion to human gingival fibroblast cells by confocal and fluorescein microscopy. FEBS JOURNAL. Vol. 283., 2016.

Ermis M. Kanser Tanı ve Tedavisinde Nanoteknoloji Uygulamaları, ODTÜ DAS, 17-19 February 2016, Ankara-Turkey (Oral presentation).

Antmen E., Ermis M., Demirci U., Hasirci V. Effect of Micropatterned Surfaces on Cell Adhesion and Nuclear Deformation of Saos-2 Cells on Collagen and PLGA Films. BIOMED, 22-24 October 2015, Antalya, Turkey (Poster presentation).

Ermis M., Calamak S., Chen P., Ulubayram K., Hasirci V., Demirci U. Micropatterned Substrates for Cell Cycle Synchronization in MDA-MB 231 Breast Carcinoma Cell Line. BIOMED, 22-24 October 2015, Antalya, Turkey (Poster presentation).

Ermis, M., Akkaynak, D., Chen, P., Demirci, U., & Hasırcı, V. Effect of Micropattern Dimensions on Adhesion, and Nuclear Shape of Osteosarcoma Cells. Society for Biomaterals 2015 Annual Meeting, 15-18 April 2015, Charlotte, NC, USA.

Hasturk O., Ermis M., Chen P., Demirci U., Hasirci V. Interaction of Nondegradable, Stiff Hydrophobic Polymers with Human Osteoblast Like Cells. BIOMED, August 24-27, 2014, Köyceğiz, Muğla, Turkey (Oral presentation).

Ucar S., Ermis M., Hasirci V., Hasirci N. Mineralized Chitosan Scaffolds for Bone Tissue Engineering Applications. BIOMED, August 24-27, 2014, Koycegiz, Mugla, Turkey (Poster presentation).

Ermis M., Antmen E., Gurkan U. A., Demirci U., Hasirci V. Effect of Micropatterned PLGA and Collagen Surfaces on Cell Adhesion and Nuclear Deformation. MRS Fall Meeting, December 1-6, 2013, Boston, MA, ABD. (Poster presentation).
Ermis M., Gurkan U. A., Demirci U., Hasirci V. Physical Functionalization of Polymeric Surfaces by Micro-Patterning of PLGA Films to Study Cell-Material Interactions. TERMIS-EU Chapter Meeting, 17-20 June 2013, Istanbul, Turkey. (Oral Presentation)

Ermis M. Artificial Intelligence in Medicine. University of Hacettepe, School of Medicine, 2nd Social Sciences in Medicine Student Congress, 24-25 May 2006, Ankara, Turkey. (Poster Presentation)

Ermis M. Hospital is Not a Building. University of Hacettepe, School of Medicine, 1st Social Sciences in Medicine Student Congress, 23-24 May 2005, Ankara, Turkey. (Oral Presentation)