BİOMATBIOMATERIALS AND TISSUE ENGINEERING RESEARCH LABORATORY


Prof. Dr. Nesrin Hasırcı

 

 

 

Title: Professor
Education:  Ph.D. METU, 1982 
M.Sc. METU, 1973
B.Sc. METU, 1971
Contact: 

Office: BIOMATEN

Telephone: +90 312 2103193      
e-mail: nhasirci@metu.edu.tr

 

Research Field

 

Biomaterials and biocompatibility: Synthesis of polymers as biomaterials, characterization, surface modification and analysis, testing of biocompatibility

 

Wound Dressing Materials: Synthesis of polymeric films, membranes and sponges for artificial skin applications and use of Growth Factors for cell proliferation and medical applications

 

Biodegradable Scaffolds: Use of polymeric matrices for cell adhesion and examine the parameters affecting cell proliferation

 

Responsive Hydrogels: Prepration and characterization of polymeric hydrogels responsive to pH and temperature and their use in controlled drug delivery

 

Enzyme Immobilization: Immobilization of enzymes on to polymeric supports for biosensor of biotechnological applications and testing of activities

 

Controlled Release: Use of Polymeric matrices in controlled release of bioactive chemicals (drugs, pesticides, herbicides etc.)

 

Bone Cement Compositions: New formulations of bone-cements with high mechanical properties

 

 

Selected Publications:


2016


  • Cerag Dilek, Nesrin Hasirci, Novendra Novendra, Supercritical processing of CO2-philic polyhedral oligomeric silsesquioxane (POSS)-poly(l-lactic acid) composites, The Journal of Supercritical Fluids, 117, 230-242, Nov 2016, (Science Citation Index) DOI:10.1016/j.supflu.2016.06.022.
  • Selva Zeynep Koklukaya, Serdar Sezer, Serpil Aksoy, Nesrin Hasirci, Polyacrylamide based semi-interpenetrating networks for entrapment of laccase and their use in azo dye decolorization, Biotechnology and Applied Biochemistry, Biotechnol Appl Biochem., 63, 5, 699–707, Oct 2016 (Science Citation Index) doi: 10.1002/bab.1417.
  • Aylin Kömez, Erkan T. Baran, Nesrin Hasirci, Vasif Hasirci, Construction of a patterned hydrogel-fibrous mat bilayer structure to mimic choroid and Bruch’s membrane layers of retina, J Biomed Mater Res A.; 104(9): 2166-2177; Sep 2016; DOI: 10.1002/jbm.a.35756.
  • Nesrin Hasirci, Cemile Kilic, Aylin Kömez, Gökhan Bahcecioglu, Vasif Hasirci, ‘Hydrogels in Regenerative Medicine’, in ‘Gels Handbook: Fundamentals, Properties and Applications, Applications of Hydrogels in Regenerative Medicine’, Ed: Mohammad Reza Abidian, Umut Gurkan, Faramarz Edalat, Ed-in-chief: Ali Khademhosseini, Utkan Demirci, World Scientific Publishing Company, Pg: 1-52, 2016
  • Seniz Ucar, Menekse Ermis, Nesrin Hasirci, Modified chitosan scaffolds: Proliferative, cytotoxic, apoptotic and necrotic effects on Saos-2 cells and antimicrobial effect on E.coli, Journal of Bioactive and Compatible Polymers, 31(3) 304–319, May 2016 (Science Citation Index) DOI: 10.1177/0883911515627471,
  • Filiz Kara, E. Ayse Aksoy, Semih Calamak, Nesrin Hasirci, Serpil Aksoy, Immobilization of heparin on chitosan grafted polyurethane films to enhance its anti-adhesive and antibacterial properties against bacteria, Journal of Bioactive and Compatible Polymers, 31(1) 72- 90, DOI: htpp://dx.doi.org/10.1177/0883911515598794, Jan 2016 (Science Citation Index)
  • GokhanBahcecioglu, Nesrin Hasirci, Vasif Hasirci, Bahar Bilgen, Differential Effects of Hydrogels on In Vitro Meniscus Regeneration, Orthopaedic Research Society Annual Meeting (ORS 2017), March 19 – 22, 2017, San Diego, California, USA
  • Nesrin Hasirci, Doku Mühendisliğinde Biyobasım: Polimerik Malzemeler, Biyoseramik Kompozitler ve Doku Özdeşleri Çalıştayı, 2 Kasım 2016, Kocaeli Üniversitesi, İzmit, TÜRKİYE
  • Tuğba Endoğan Tanir, Elif Vargün, Nesrin Hasirci, Platelet Adhesion and Protein Adsorption on Heparin Immobilized Graphene Enhanced Poly(Acrylonitrile-co-Ethyl Methacrylate) Membranes, 46th IUPAC World Polymer Congress (MACRO 2016), 17-21 July 2016, Istanbul, Turkey
  • Eda Ayse Aksoy, Filiz Kara, Nesrin Hasirci, Serpil Aksoy, Improving Antibacterial Efficacy of Chitosan Grafted Polyurethanes with Silver Nanoparticles, 46th IUPAC World Polymer Congress (MACRO 2016), 17-21 July 2016, Istanbul, Turkey
  • Nesrin Hasirci, 3D printed PCL based composites for bone tissue engineering Applications, Summer School on Tissue Engineering and Regenerative Medicine, 4-9 July 2016, Riva del Garda, Italy
  • Ayse Selcen Alagoz, Jose Carlos Rodriguez-Cabello, Nesrin Hasirci, Vasif Hasirci, Wet Spun Scaffolds of PHA-PLA Blend for Bone Tissue Engineering, European Chapter Meeting of the Tissue Engineering and Regenerative Medicine International Society 2016, 28 June-1 July, 2016, Uppsala, Sweden
  • Nesrin Hasirci, Multifunctional polymeric composites: Bioactive, biodegradable, antithrombogenic and antimicrobial, 10th World Biomaterials Congress, 17-22 May 2016, Montreal Canada
  • Ayse Eda Aksoy, Filiz Kara, Tuba Tuylu Kucukkilinc, Serpil Aksoy, Nesrin Hasirci, Adsorption of Plasma Proteins on Multi Layer Surface Modified Polyurethane Films, 10th World Biomaterials Congress, 17-22 May 2016, Montreal Canada
  • Elbay Malikmammadov, Tugba T. Endogan, Aysel Kiziltay, Vasif Hasirci, Nesrin Hasirci, Surface modified multi-functional PCL/TCP fibrous scaffolds, 10th World Biomaterials Congress, 17-22 May 2016, Montreal Canada
  • Nesrin Hasirci, Modification of Surfaces to Create Antithrombogenic and Antibacterial Properties, EMN on Biomaterials, 4-6 April, 2016 Phuket, Tayland
  • Nesrin Hasirci, Chemistry, Biomaterials and Artificial Organs, Chemistry Discussions@ Bilkent, 1 April 2016, Ankara
  • Nesrin Hasirci, Biomedical Materials and Artificial Organs, METU Graduate School of Natural and Applied Science -17 March 2016, Ankara
  • Nesrin Hasirci, Biyomalzemeler ve Biyomedikal, Ar-Ge Strateji Belgesi Hazırlanması, Biyomedikal Alanı 1. Çalıştayı, 25 Şubat 2016, ODTU Ankara
  • Nesrin Hasirci, Vasif Hasirci, BIOMATEN ve BİYOMALZEMELER, Teknoloji Basın Toplantısı - 12 Şubat 2016, ODTU Ankara

2015

  • Filiz Kara, Eda Ayse Aksoy, Zehranur Yuksekdag, Serpil Aksoy, Nesrin Hasirci, Enhancement of Antibacterial Properties of Polyurethanes by Chitosan and Heparin Immobilization, Applied Surface Science, DOI: 10.1016/j.apsusc.2015.09.227, 357: 1692–1702, December 2015
  • Ufuk Ates, Gulnur Gollu, Meltem Bingol-Kologlu, Deniz Billur, Gonul Kucuk, Nihan Oruklu, Umit Bagrıacik, Nesrin Hasırcı and Huseyin Dindar, The Effects of Local and Systemic Growth Hormone Treatment on Germ Cell Population and Fertility in an Experimental Unilateral Testicular Torsion and Orchiectomy Model, The Journal of Urology, http://dx.doi.org/10.1016/j.juro.2015.07.087,  194:1816-1822, December 2015
  • Tugba Endogan Tanir, Vasif Hasirci, Nesrin Hasirci, Preparation and Characterization of Chitosan and PLGA Based Scaffolds for Tissue Engineering Applications, Polymer Composites, DOI:10.1002/pc.23100, 36(10): 1917–1930, October 2015
  • Gozde Eke, Felipe Goñi-de-Cerio, Blanca Suarez-Merino, Nesrin Hasirci, and Vasif Hasirci, Biocompatibility of Dead Sea Water and Retinyl Palmitate Carrying Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) micro/nanoparticles Designed for Transdermal Skin Therapy, Journal of Bioactive and Compatible Polymers, 30,5, 455-471, September 2015
  • Aysel Kızıltay, Angel M. Fernandez, Julio San Roman, Rui A. Sousa, Rui L. Reis, Vasif Hasirci, Nesrin Hasirci, Poly(ester-urethane) scaffolds: Effect of structure on properties and osteogenic activity of stem cells, Tissue Engineering and Regenerative Medicine, DOI: 10.1002/term.1848, 9:930-942, August 2015
  • Shahla Bagherifam, Frode Miltzow Skjeldal, Gareth Griffiths,  Gunhild M. Mælandsmo, Bo Nyström, Vasif Hasirci, Nesrin Hasirci, pH-Responsive Nano Carriers for Doxorubicin Delivery, Pharmaceutical Research, Pharm Res, DOI 10.1007/s11095-014-1530-0, 32: 1249–1263, April 2015
  • Eda Ayse Aksoy, Umran Aydemir Sezer, Filiz Kara, Nesrin Hasirci, Heparin/Chitosan/Alginate Complex Scaffolds as Wound Dressings: Characterization and Antibacterial Study against S. Epidermidis, Journal of Biomaterials and Tissue Engineering, doi:10.1166/jbt.2015.1296, Vol. 5, 1–10, February 2015
  • Maria Teresa Calejo, Nesrin Hasirci, Shahla Bagherifam, Reidar Lund and Bo Nyström, Self-assembled Stimuli-Responsive Structures from Cationic Polymers for Biomedical Applications (Chapter 6),  in Cationic Polymers in Regenerative Medicine, Eds: Sangram Samal, Peter Dubruel,  Royal Society of Chemistry (RSC publisher), DOI:10.1039/9781782620105, pp: 149-177, January 2015
  • Shahla Bagherifam, Gareth W. Griffiths, Gunhild M. Mælandsmo, Bo Nyström, Vasif Hasirci, Nesrin Hasirci, Poly(sebacic anhydride) Nanocapsules as Carriers: Effects of Preparation Parameters on Properties and Release of Doxorobucin, Journal of Microencapsulation, J Microencapsul. ID: 973073 DOI:10.3109/02652048.2014.973073, 32(2): 166–174, January 2015
  • Bagherifam, S., Skjeldal, F. M., Griffiths, G., Mælandsmo, G. M., Engebråten, O., Nyström, B., Hasirci, V., Hasirci, N. (2015). pH-Responsive Nano Carriers for Doxorubicin Delivery. Pharmaceutical Research, 1249-1263.

 

2014

  • Bagherigam, S., Griffiths, G. W., Mælandsmo, G. M., Nyström, B., Hasirci, V., & Hasirci, N. (2014). Poly(sebacic anhydride) nanocapsules as carriers: effects of preparation parameters on properties and release of doxorubicin. Journal of Microencapsulation, 1-9.

  • Eke, G., Kuzmina, A. M., Goreva, A. V., Shishatskaya, E. I., Hasirci, N., & Hasirci, V. (2014). In vitro and transdermal penetration of PHBV micro/nanoparticles. Journal of Materials Science: Materials in Medicine, 1471-1481.

  • Endogan Tanir, T., Hasirci, V., & Hasirci, N. (2014). Electrospinning of Chitosan and PLGA Based Nanofibrous Mats for Tissue Engineering Applications. Polymer Bulletin, 2999-3016.

  • Endogan, T., Kiziltay, A., Kose, G., Comunoglu, N., Beyzadeoglu, T., & Hasirci, N. (2014). Acrylic bone cements: Effects of the poly(methyl methacrylate) powder size and chitosan addition on their properties. Journal of Applied Polymer Science, 1-8.

  • Endogan-Tanir, T., Hasirci, V., & Hasirci, N. (2014). Electrospinning of chitosan/poly(lactic acid-co-glycolic acid)/hydroxyapatite composite nanofibrous mats for tissue engineering applications. Polymer Bulletin, 2999-3016.

  • Endogan-Tanir, T., Hasirci, V., & Hasirci, N. (2014). Preparation and Characterization of Chitosan and PLGA-Based Scaffolds for Tissue Engineering Applications. Polymer Composites, 1-14.

  • Guney, A., & Hasirci, N. (2014). Properties and Phase Segregation of Crosslinked PCL-Based Polyurethanes. Journal of Applied Polymer Science, 1-13.

  • Halili, A. N., Hasirci, N., & Hasirci, V. (2014). A multilayer tissue engineered meniscus substitute. Journal of Materials Science: Materials in Medicine, 1195-1209.

  • Hasırcı N. Polimer-İlaç ve Polimer-Protein Konjugatları, Ed: Ayla Zırh Gürsoy, Nanofarmasötikler ve Uygulamaları, Kontrollu Salım Sistemleri Derneği Yayını, ISBN: 978-605-85318-0-2, No:3, 151-166, March, 2014

  • Kara, F., Aksoy, E., Yuksekdag, Z., Hasirci, N., & Aksoy, S. (2014). Synthesis and surface modification of polyurethanes with chitosan for antibacterial properties. Carbohydrate Polymers, 39–47.

  • Kızıltay A., Hasirci N. Biodegradable (ester-urethane) scaffolds prepared for bone tissue engineering, Putech, Polyurethane Industry Magazine, 5:19, 10-26, January 2014,

  • Ozgen, O., & Hasirci, N. (2014). Modification of Poly(methyl methacrylate) Surfaces with Oxygen, Nitrogen and Argon Plasma. Journal of Biomaterials and Tissue Engineering, 479-487.

  • Saygun, I., Bal, V., Kızıltay, A., Huri, P. Y., Avcu, F., Üstün, K., Hasirci, V., Hasirci, N. (2014). Proliferation and Differentiation of Mesenchymal Stem Cells in Chitosan Scaffolds Loaded with Nanocapsules Containing Bone Morphogenetic Proteins-4, Platelet-Derived Growth Factor and Insulin-Like Growth Factor 1. Journal of Biomaterials and Tissue Engineering,, 181-188.

  • Sezer, U., Arslantunali, D., Aksoy, E., Hasirci, V., & Hasirci, N. (2014). Poly(ε-caprolactone) composite scaffolds loaded with gentamicin-containing β-tricalcium phosphate/gelatin microspheres for bone tissue engineering applications. Journal of Applied Polymer Science, 1-11.

  • Sezer, U., Billur, D., Huri, G., Huri, P., Aksoy, E., Terzioglu, H., Hasirci, V., Hasirci, N. (2014). In vivo performance of poly(ɛ-caprolactone) constructs loaded with gentamicin releasing composite microspheres for use in bone regeneration. Journal of Biomaterials and Tissue Engineering, 786-795.

 

  • Sezer, U., Billur, D., Huri, G., Huri, P., Aksoy, E., Terzioglu, H., Konukseven, E., Hasirci, V., Hasirci, N. (2014). In Vivo Performance of Poly(ε-caprolactone) Constructs Loaded with Gentamicin Releasing Composite Microspheres for Use in Bone Regeneration. Journal of Biomaterials and Tissue Engineering, 786-795.

 

2013

  • Endogan, T., Ozyaylali, I., Kulacoglu, H., Serbetci, K., Kiyak, G., & Hasirci, N. (2013). Effects of ethylene oxide resterilization and in-vitro degradation on mechanical properties of partially absorbable composite hernia meshes. Chirurgia, 840-848.

  • Gunbas, I., Sezer, U., Iz, S., Gurhan, I., & Hasirci, N. (2012). Semi-IPN Chitosan/Polyvinylpyrrolidone Microspheres and Films for Biomedical Applications: Sustained Release and Physical Property Optimization. Industrial & Engineering Chemistry Research, 11946–11954.

  • Guney, A., Kara, F., Ozgen, O., Aksoy, E., Hasirci, V., & Hasirci, N. (2013). 5. Surface Modification of Polymeric Biomaterials. Biomaterials Surface Science, 89–158.

  • Huri, P., Huri, G., Yasar, U., Ucar, Y., Dikmen, N., Hasirci, N., & Hasirci, V. (2013). A biomimetic growth factor delivery strategy for enhanced regeneration of iliac crest defects. Biomedical Materials, 1-8.

  • Kiziltay, A., Marcos-Fernandez, A., Roman, J. S., Sousa, R. A., Reis, R. L., Hasirci, V., & Hasirci, N. (2013). Poly(ester-urethane) scaffolds: Effect of structure on properties and osteogenic activity of stem cells. Journal of Tissue Engineering and Regenerative Medicine.

  • Ndreu Halili, A., Hasirci, N., & Hasirci, V. (2013). A Mechanically Functional Collagen-Based Construct Designed as a Meniscus Substitute. Journal of Biomaterials and Tissue Engineering, 173-184.

  • Ozgen, O., Aksoy, E., Hasirci, V., & Hasirci, N. (2013). Surface Characterization and Radical Decay Studies of Oxygen Plasma Treated PMMA Films. Surface and Interface Analysis, 844-853.

  • Sezer, U., Aksoy, E., Hasirci, V., & Hasirci, N. (2012). Poly(ε-caprolactone) composites containing gentamicin loaded β-TCP/Gelatin microspheres as bone tissue supports. Journal of Applied Polymer Science, 1-8.

  • Ucar, S., Yilgor, P., Hasirci, V., & Hasirci, N. (2013). Chitosan-based wet-spun scaffolds for bioactive agent delivery. Journal of Applied Polymer Science, 3759-3769.

  • Yilgor, P., Yilmaz, G., Onal, M. B., Solmaz, I., Gundogdu, S., Keskil, S., Sousa, RA., Reis, RL., Hasirci, N., Hasirci, V. (2013). An in vivo Study on Effect of Scaffold Geometry and Growth Factor Release on the Healing of Bone Defects. Journal of Tissue Engineering and Regenerative Medicine, 687-696.

 

2012

  • Gunbas, I., Sezer, U., Iz, S., Gurhan, I., & Hasirci, N. (2012). Semi-IPN Chitosan/Polyvinylpyrrolidone Microspheres and Films for Biomedical Applications: Sustained Release and Physical Property Optimization. Industrial & Engineering Chemistry Research, 11946–11954.

  • Isikli, C., Hasirci, V., & Hasirci, N. (2012). Development of porous chitosan-gelatin/ hydroxyapatite composite scaffolds for hard tissue-engineering applications. Journal of Tissue Engineering and Regenerative Medicine, 135-143.

  • Sezer, U., Aksoy, E., Hasirci, V., & Hasirci, N. (2012). Poly(ε-caprolactone) composites containing gentamicin loaded β-TCP/Gelatin microspheres as bone tissue supports. Journal of Applied Polymer Science, 1-8.

 

2011

  • Carletti, E., Endogan, T., Hasirci, N., Hasirci, V., Maniglio, D., Motta, A., & Migliaresi, C. (2011). Microfabrication of PDLLA scaffolds. Journal of Tissue Engineering and Regenerative Medicine, 569-577.

  • Hasirci, V., Yilgor, P., Endogan, T., Eke, G., & Hasirci, N. (2011). Polymer Fundamentals: Polymer Synthesis. In P. Ducheyne, Comprehensive Biomaterials (pp. 349-371). Elsevier.

 

2010

  • Bingol-Kologlu, M., Bahadir, B. G., Vargun, R., Ilkay, H., Bagriacik, U. E., Yolbakan, S., Guven, C., Endogan, T., Hasirci, N., Dindar, H. (2010). Effects of Local and Sustained Release of FGF, IGF, and GH on Germ Cells in Unilateral Undescended Testis in Rats. Journal of Urology, 223-228.

  • Hasirci, N., Endogan, T., Vardar, E., Kiziltay, A., & Hasirci, V. (2010). Effect of Oxygen Plasma on Surface Properties and Biocompatibility of PLGA Films. Surface and Interface Analysis, 486-491.

  • Makas, G. Y., Kalkan, A. N., Aksoy, S., Altinok, H., & Hasirci, N. (2010). Immobilization of laccase in K-carrageenan based semi-interpenetrating polymer networks. Journal of Biotechnology, 216-220.

  • Tunc, Y., Golgelioglu, C., Hasirci, N., Ulubayram, K., & Tuncel, A. (2010). Acrylic-based high internal phase emulsion polymeric monolith for capillary electrochromatography. Journal of Chromatography A, 1654-1659.

  • Yilgor, P., Hasirci, N., & Hasirci, V. (2010). Sequential BMP-2/BMP-7 Delivery from Polyester Nanocapsules. Journal of Biomedical Materials Research: Part A, 528-536.

  • Yilgor, P., Sousa, R. A., Reis, R. L., Hasirci, N., & Hasirci, V. (2010). Effect of scaffold architecture and BMP-2/BMP-7 delivery on in vitro bone regeneration. Journal of Materials Science: Materials in Medicine, 2999-3008.

 

2009

  • Dogan, S., Demirer, S., Kepenekci, I., Erkek, B., Kiziltay, A., Hasirci, N., Muftuoglu, S., Nazikoglu, A., Renda, N., Dincer, U D., Elhan, A.,  Kuterdem, E. (2009). Epidermal growth factor-containing wound closure enhances wound healing in non-diabetic and diabetic rats. International Wound Journal, 107-115.

  • Endogan, T., Serbetci, K., & Hasirci, N. (2009). Effects of Ingredients on Thermal and Mechanical Properties of Acrylic Bone Cements. Journal of Applied Polymer Science, 4077-4084.

  • Karahan, M. A., Kulacoglu, H., Seker, D., Ergul, Z., Kiziltay, A., Yilmazer, D., . . . Hasirci, N. (2009). How safe is the use of prosthetic materials in the repair of abdominal-wall defects in malnourished subjects. Central European Journal of Medicine, 331-336.

  • Yamak, O., Kalkan, A. N., Aksoy, S., Altinok, H., & Hasirci, N. (2009). Semi-interpenetrating polymer networks (semi-IPNs) for entrapment of laccase and their use in Acid Orange 52 decolorization. Process Biochemistry, 440-445.

  • Yilgor, P., Tuzlakoglu, K., Reis, R. L., Hasirci, N., & Hasirci, V. (2009). Incorporation of a sequential BMP-2/BMP-7 delivery system into chitosan-based scaffolds for bone tissue engineering. Biomaterials, 3551–3559.

 

2008

  • Aksoy, A. E., Hasirci, V., & Hasirci, N. (2008). Surface Modification of Polyurethanes with Covalent Immobilization of Heparin. Macromolecular Symposia, 145-153.

  • Aksoy, E. A., Hasirci, V., Hasirci, N., Motta, A., Fedel, M., & Migliaresi, C. (2008). Plasma Protein Adsorption and Platelet Adhesion on Heparin-Immobilized Polyurethane Films. Journal of Bioactive and Compatible Polymers , 505-519.

  • Altinok, H., Aksoy, S., Tumturk, H., & Hasirci, N. (2008). Covalent Immobilization of Invertase on Chemically Activated Poly(Styrene-2-hydroxyethyl methacrylate) Microbeads. Journal of Food Biochemistry, 299-315.

  • Fedakar-Senyucel, M., Bingol-Kologlu, M., Vargun, R., Akbay, C., Sarac, N. F., Renda, N., Hasirci, N., Gollu, G., Dindar, H. (2008). The effects of local and sustained release of Fibroblast growth factor on wound healing in esophageal anastomoses. Journal of Pediatric Surgery, 290-295.

  • Kamisoglu, K., Aksoy, E. A., Akata, B., Hasirci, N., & Bac, N. (2008). Preparation and Characterization of Antibacterial Zeolite - Polyurethane Composites. Journal of Applied Polymer Science, 2854-2861.

  • Oruc, M., Ulusoy, M. G., Kankaya, Y., Kocer, U., Serbetci, K., & Hasirci, N. (2008). Pulley reconstruction with different materials: Experimental study. Annals of Plastic Surgery, 215-220.

  • Ozcan, C., & Hasirci, N. (2008). Evaluation of Surface Free Energy for PMMA Films. Journal of Applied Polymer Science, 438-446.

  • Ozcan, C., Zorlutuna, P., Hasirci, V., & Hasirci, N. (2008). Influence of Oxygen Plasma Modification on Surface Free Energy of PMMA Films and Cell Attachment. Macromolecular Symposia, 128-137.

  • Tumturk, H., Demirel, G., Altinok, H., Aksoy, S., & Hasirci, N. (2008). Immobilization of Glucose Isomerase in Surface Modified Alginate Gel Beads. Journal of Food Biochemistry, 234-246.

  • Uguralp, S., Akin, M., Karabulut, A. B., Harma, B., Kiziltay, A., Kiran, T. R., & Hasirci, N. (2008). Reduction of peritoneal adhesions by sustained and local administration of epidermal growth factor. Pediatric Surgery International, 191-197.

  • Yilgor, P., Sousa, R. A., Reis, R. L., Hasirci, N., & Hasirci, V. (2008). 3D Plotted PCL Scaffolds for Stem Cell Based Bone Tissue Engineering. Macromolecular Symposia, 92-99.

  • Zorlutuna, P., Hasirci, N., & Hasirci, V. (2008). Nanopatterned collagen tubes for vascular tissue engineering. Journal of Tissue Engineering and Regenerative Medicine, 373-377.

 

2007

  • Aksoy, E. A., Akata, B., Bac, N., & Hasirci, N. (2007). Preparation and characterization of zeolite Beta-polyurethane composite membranes. Journal of Applied Polymer Science, 3378-3387.

  • Hasirci, N. (2007). Micro and Nano Systems in Biomedicine and Drug Delivery. In R. M. Mozafari, Nanomaterials and Nanosystems for Biomedical Applications (pp. 1-26). Springer Netherlands.

  • Hasirci, N., & Aksoy, E. A. (2007). Synthesis and Modification of Polyurethanes for medical Applications. High Performance Polymers, 621-637.

  • Karakayali, F., Haberal, N., Tufan, H., Hasirci, N., Basaran, O., Sevmis, S., Akdur, A., Kiziltay, A., Haberal, M. (2007). Evaluation of neointimal hyperplasia on tranilast-coated synthetic vascular grafts: An experimental study. Journal of Investigative Surgery, 161-173.

  • Ozcan, C., & Hasirci, N. (2007). Plasma modification of PMMA films, surface free energy and cell-attachment studies. Journal of Biomaterials Science, Polymer Edition, 759-773.

  • Serbetci, K., Kulacoglu, H., Devay, A. O., & Hasirci, N. (2007). Effects of Resterilization on Mechanical Properties of Polypropylene Meshes. The American Journal of Surgery, 375-379.

 

2006

  • Altinok, H., Aksoy, S., Tumturk, H., & Hasirci, N. (2006). Covalent immobilization of invertase on chemically activated poly(2-hydroxyethyl methacrylate) microbeads. Russian Chemical Bulletin, 1860-1864.

  • Basgorenay, B., Ulubayram, K., Serbetci, K., Onurhan, E., & Hasirci, N. (2006). Preparation modification and characterization of acrylic cements. Journal of Applied Polymer Science, 3631-3637.

  • Demirel, G., Ozcetin, G., Sahin, F., Tumturk, H., Aksoy, S., & Hasirci, N. (2006). Semi-Interpenetrating polymer networks (IPNs) for entrapment of Glucose Isomerase. Reactive and Functional Polymers, 389-394.

  • Hasirci, N., Aksoy, S., & Tumturk, H. (2006). Activation of poly(dimer acid-co-alkyl polyamine) particles for covalent immobilization of a-amylase. Reactive and Functional Polymers, 1546-1551.

  • Tunc, Y., Hasirci, N., Yesilada, A., & Ulubayram, K. (2006). Comonomer Effects on Binding Performances and Morphology of Acrylate-Based Imprinted Polymers. Polymer, 6931-6940.

  • Yildirim, M. S., Kesimer, M., Hasirci, N., Kilic, N., & Hasanreisoglu, U. (2006). Adsorption of human salivary mucin MG1 onto glow-discharge plasma treated acrylic resin surfaces. Journal of Oral Rehabilitation, 775-783.

 

2005

  • Hasirci, V., & Hasirci, N. (2005). Control of Polymeric Biomaterial Surfaces. In P. Vadgama, Surfaces and Interfaces for Biomaterials (pp. 29-59). Cambridge, England: CRC Press, Boca Raton, Woodhead Pub.Limited.

  • Muvaffak, A., Gurhan-Deliloglu, I., Gunduz, U., & Hasirci, N. (2005). Preparation and characterization of a   biodegradable drug targeting system for anticancer delivery: Microsphere-antibody conjugate. Journal of Drug Targeting, 151-159.

  • Oylum, H., Yilmaz, E., Bengisu, M., & Hasirci, N. (2005). Preparation and Characterization of Chitin Gels-A Comparative Study. In H. Struszyk, A. Domard, M. G. Peter, & H. Pospieszny, Advances in Chitin Science (pp. 426-429). ESUS, Poznan, Poland.

  • Ulubayram, K., Kiziltay, A., Yilmaz, E., & Hasirci, N. (2005). Desferrioxamine release from gelatin based sytems. Biotechnology and Applied Biochemistry, 237-245.

  • Yildirim, M. S., Hasanreisoglu, U., Hasirci, N., & Sultan, N. (2005). Adherence of Candida albicans to glow-discharge modified acylic denture base polymers. Journal of Oral Rehabilitation, 518-525.

 

2004

  • Hasirci, V., Korkusuz, F., Akkas, N., Bayramli, E., Hasirci, N., Severcan, F., Timucin, M., Alaeddinoglu, G. (2004). Production of Microbial Polyesters and Their Application in the Construction of Biodegradable, Controlled Antibiotic Release Systems. In M. J. Yaszemski, D. J. Trantolo, K. Lewandrowski, V. Hasirci, D. E. Altobelli, & D. L. Wise, Tissue Engineering and Novel Delivery Systems (pp. 281-303). New York: Marcel-Dekker Inc.

  • Muvaffak, A., Gurhan, I., & Hasirci, N. (2004). Cytotoxicity of 5-fluorouracil entrapped in gelatin microspheres. Journal of Microencapsulation, 293-306.

  • Muvaffak, A., Gurhan, I., & Hasirci, N. (2004). Prolong cytotoxic effect colchicines released from biodegradable microspheres. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 295-304.

  • Sakallioglu, E. A., Yagmurlu, A., Dindar, H., Hasirci, N., Renda, N., & Deveci, S. M. (2004). Sustained Local Application of Low-Dose Epidermal Growth Factor on Steroid-Inhibited Colonic Would Healing. Journal of Pediatric Surgery, 591-595.

  • Serbetci, K., & Hasirci, N. (2004). Recent Developments in Bone Cements. In M. J. Yaszemski, D. J. Trantolo, K. Lewandrowski, V. Hasirci, D. E. Altobelli, & D. L. Wise, Biomaterials in Orthopedics (pp. 241-286). New York: Marcel-Dekker Inc.

  • Serbetci, K., Korkusuz, F., & Hasirci, N. (2004). Thermal and Mechanical Properties of Hydroxyapatite Impregnated Acrylic Bone cements. Polymer Testing, 145-155.

  • Uguralp, S., Bay Karabulut, A., Mizrak, B., Kaymaz, F., Kiziltay, A., & Hasirci, N. (2004). The Effect of Sustained and Local Administration of Epidermal Growth Factor on Improving Bilateral Testicular Tissue After Torsion. Urological Research, 323-331.

 

2003

  • Hasirci, V., Tezcaner, A., Hasirci, N., & Suzer, S. (2003). Oxygen Plasma Modification of poly (3-hydroxy butyrate-co-3-hydroxy valerate) film surfaces for tissue engineering purposes. Journal of Applied Polymer Science, 1285-1289.

  • Kose, G. T., Kenar, H., Hasirci, N., & Hasirci, V. (2003). Macroporous Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) Matrices for Bone Tissue Engineering. Biomaterials, 1949-1958.