BIO 414 - Biomedical Materials and Instrumentation

Goals:

This course is designed to familiarize the students with two important aspects of the biological field at an introductory level. The first part deals with biomedical applications of materials obtained from natural and synthetic sources and covers interactions between the body and the material, guidelines for biocompatibility and selection of appropriate electronic apparatus, etc., used in biomedical instrumentation systems.

 

Credits	(3-0) 3
Prerequisite	Consent of the Instructor

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BIO 514 - Biomaterials

Goals:

The multidisciplinary subject of biomedical application of materials obtained from natural and synthetic sources. Solid properties, various materials used in biomaterials, tissue-material interactions, in situ, in vitro and in vivo application methods and sterilization are discussed. Important soft and hard tissue applications involving tissue engineering, drug delivery, implant design, and imaging are discussed with special emphasis on bio and synthetic polymers.

Course Outline:

• The Structure of Solids
• Characterization of Materials
• Metallic Implant Materials
• Ceramic Implant Materials
• Polymeric Implant Materials
• Composites as Biomaterials
• Structure-Property Relationships of Biological Materials
• Tissue Response to Implants
• Soft Tissue Replacement- Sutures, skin, maxillofacial, blood-interfacing implants
• Hard Tissue Replacements- Long bone repair, joints and teeth
• Transplants
• Selected Papers

 

Text Book:

Biomaterials, J.B.Park and R.S.Lakes, Plenum , 1992

 

Reference Books:

• Mechanical Testing of Bone and The Bone-Implant Interface, Y.H. An, R.A.Draughn, CRC Press 2000
• Principles of Tissue Engineering, R.P.Lanza, R.Langer, W.L.Chick, Academic Press, 1997
• Biotechnology and Bioactive Polymers, C.G.Gebelein, C.H.Carraher,Jr., Plenum Press,1994
• Immobilized Macromolecules, U.B.Sleyr, P.Messner, D.Pum, M.Sara, Springer-Verlag,1993

 

Reference Journals:

Many journals including Biomaterials, J. Biomedical Materials Research, J. Materials Science: Materials in Medicine, J. Controlled Release, J. Microencapsulation, J. Biomaterials Science: Polymer Edition, and Tissue Engineering are among the sources from which the students will be given reading material.

Credits	(3-0) 3
Prerequisite	Consent of the Instructor

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BIO 554 - Macromolecules in Biotechnology and Biomedicine

Goals:

Classification, synthesis and transformation of biopolymers (polynucleotides, polypeptides and polysaccharides). Merrifield solid state synthesis. Classification, synthesis and transformation of synthetic macromolecules. Chemical and biological transformation. Solution behavior, helix-coil transition. Structure, morphology and properties of biological polymers in the solid state. Single crystal formation. Applications in Biomedicine and Biotechnology.(S/WE)*

 

Course Outline:

• Introduction
• Classification of Macromolecular Compounds
• MW and Polymolecularity
• Synthesis of Synthetic Polymers
• Synthesis of Macromolecules With Heteroatoms In The Chain Via Polycondensation
• Solid State Synthesis of Proteins
• Strategies For Chemical Synthesis of DNA
• Chemical Transformation
• The Macromolecular Solution
• The Peptide Bond Structure and Morphology of Biopolymers
• a-Helix and Single crystal
• Free Energies, Bonding Types and Conformation
• Packing density
• Macromolecular Symmetry
• Specific Biopolymers
• Recent Papers

 

Reference Books:

• Biotechnology and Bioactive Polymers, C.G.Gebelein, C.H.Carraher, Jr., Plenum Press, 1994
• Immobilized Macromolecules, U.B.Sleyr, P.Messner, D.Pum, M.Sara, Springer- Verlag,1993
• Biosensors, A.E.G.Cass, IRL Press,1990
• Biopolymers, A.G.Walton, J.Blackwell, S.H.Carr, Academic Press, 1973
• Biophysical Chemistry, C.R.Cantor, P.R.Schimmel, W.H.Freeman and Co.,1980
• Polysaccharides, E.D.T.Atkins, Macmillan,1985

Credits	(3-0) 3
Prerequisite	Consent of the Instructor

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BIO 580 - Controlled Release Systems and Drug Targeting

Goals:

Overview of the approaches to bioactive agent administration and systems used in the targeting and delivery of biologically active materials and their fate in the body. Carriers such as liposomes, colloidal carriers, membranes, and biodegradable systems are to be covered. Approaches to genetic material delivery relevant with gene therapy and various anticancer, pain relief, and antibiotic administration are discussed using current literature.

Credits	(3-0) 3
Prerequisite	Consent of the Instructor

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BIO 584 - Advanced Biomaterials

Goals:

The most important and novel topics of the biomaterials field are studied in the form of discussion using the latest literature: Testing of biomaterials, biostability, mechanisms of degradation, bio-and hemocompatibility of materials, sterilization of biomedical devices, cell-biomaterial interactions, drug delivery via biodegradable vehicles, hard and soft tissue augmentation, implants, dental applications and bone cements, tissue engineering, biomedical instrumentation and imaging.

 

Course Outline:

• A Review of Basic Biomaterials Concepts 
• Testing of Biomaterials- Physical, Chemical, and Biological (in situ, in vitro, in vivo and clinical) testing methods
• Biostability, Mechanisms of Degradation and Biodegradable Materials 
• Biocompatibility and Hemocompatibility, and Routes of Improvement 
• Sterilization of Biomedical Devices
• Tissue Engineering and Cell-Biomaterials Interactions - Cartilage, tendon, nerve guide, liver 
• Drug Delivery
• Soft Tissue Augmentation
• Hard Tissue Implants and Bone Cements
• Dental Applications
• Biomedical Instrumentation and Imaging
• Biotechnology and Biomaterials

 

Reference Book(s) and Papers:

• Principles of Tissue Engineering, R.P.Lanza, R. Langer, W.L.Chick, Academic Press, 1997
• Human Biomaterials Applications, D.L.Wise, et al., Humana Press, 1996
• Polymeric Biomaterials, S.Dimitriu, Marcel Dekker, 1993
• Biodegradable Implants in Fracture Fixation, L. Kwok-sui et al.,World Scientific, 1994

 

Reference Journals:

Biomaterials incorporating Clinical Applications, J. Controlled Release , J. Materials Science: Materials in Medicine, Biomaterials, Tissue Engineering, J. Biomaterials Science: Polymer Edition.

Credits	(3-0) 3
Prerequisite	Consent of the Instructor